Objective: To explore the effect of nursing combined with white noise intervention under stress adaptation theory in NICU premature infants. Methods: A total of 120 premature infants in our NICU from November 2024 to March 2025 were randomly divided into control group and observation group, with 60 cases in each group. The control group received routine nursing, while the observation group received nursing combined with white noise intervention under stress adaptation theory . Comfort, sleep quality , and growth and development were compared between the two groups. Results: The simplified COMFORT scale score in the observation group was higher than that in the control group (P