Introduction: Nurses' Occupational Death Avoidance (ODA) reflects their multidimensional responses in death-related contexts. Understanding ODA among Pediatric Intensive Care Unit (PICU) nurses is crucial for improving their coping skills and palliative care quality . Aim: This study aimed to investigate ODA status, identify its latent profiles, and explore the impact of perceived interpersonal exchange and information competency on ODA. Methods: A cross-sectional survey was conducted among 542 PICU nurses from 15 tertiary hospitals in Hubei Province, China (Dec 2020-Jan 2021). Data were collected using the Nurses' Occupational Death Avoidance Scale (NODAS), Perceived Interpersonal Exchange Questionnaire, and Information Competency Scale. Latent profile analysis and multivariate logistic regression were used. Results: Three NODAS profiles were identified: low (36.34%), medium (47 .42%), and high (16.24%). Higher perceived interpersonal exchange and information competency were significantly associated with lower ODA. Nurses with 6-10 years of PICU experience were significantly less likely to exhibit high ODA (OR=0.301, p=0.015). Conclusion: ODA among PICU nurses falls into three subgroups. Those with 6-10 years of experience, higher interpersonal exchange, and information competency demonstrate lower ODA.