Abstract Ref Number = APCP997
CORD BLOOD VITAMIN D LEVEL IN TERM NEWBORN
Yeni Konga Ala Kula Awang,Agustini Utari,Rina Pratiwi ,JC Susanto ,Maria Mexitalia
Department of Pediatrics, Faculty of Medicine, Diponegoro University Dr Kariadi Hospital Semarang, Indonesia
Background : The Clinical Guidelines Subcommittee of The Endocrine Society suggest that infants and children age 0 - 1 year require at least 400 IU/d vitamin D supplementation to maximize bone health. In Indonesia the occurence of cord blood vitamin D insufficiency/deficiency has not been adequately explored. The study aims is to describe the status of vitamin D levels in term newborns at birth in Indonesia.
Material : The study was performed from June 2017 – Maret 2018. A total of 52 pregnant women with no history of chronic diseases before pregnancy were included in the study. Cord blood samples at term newborn were collected at the delivery time. The 25 – hydroxyvitamin D [25(OH)D] levels was analyzed by the enzyme-linked immunosorbent assay (ELISA). Based on the Clinical Practice Guidelines published by the Endocrine Society we classified the cord blood levels of 25(OH)D as sufficient (>30 ng/mL), insufficient (21 – 29 ng/mL) and deficient (<20 ng/mL).
Results : There were 52 newborns who participated this study. We found 26 (50%) newborns had vitamin D deficiency, 21 (40%) insufficiency, and 5 (10%) sufficiency. Among newborns, 28 (53.8%) male and 24 (46.2%) female, 36 (69.2%) were born by normal vaginal delivery, 3 (5.8%) were low birth weight and 49 (94.2%) were normal birth weight. Of 52 mothers, 11 (21.2 8%) were high risk mothers, 23 (44.2%) were educated in senior high school, 35 (67.3%) were housewife, and 34 (65.4%) mothers with multiple gestation.
Conclusions : This study suggested that vitamin D deficiency is common among newborn period. Vitamin D supplementation is recommended at infant period.
Keywords: Vitamin D 25(OH)D cord blood deficient