Abstract Ref Number = APCP929
A SIX YEAR REVIEW OF CHILDREN WITH NEUROBLASTOMA AT DR SARDJITO GENERAL HOSPITAL YOGYAKARTA INDONESIA 2012-2017
Scolastika Dita Kristian,Agustina Istaryanti,Ahmad Heri Setiawan,Sri Mulatsih,Sutaryo
Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada Dr Sardjito General Hospital
Background : Neuroblastoma is the third largest tumor in children after leukemia and retinoblastoma. It is clinically presenting with a wide range of symptoms. This study aimed to analyze clinical profiles of children diagnosed with neuroblastoma in Dr. Sardjito General Hospital.
Material : A retrospective review of children under 18 years old with neuroblastoma in inpatient ward of Dr. Sardjito General Hospital from 2012-2017. Patient who was diagnosed and treated in other hospitals was excluded. Data were taken from medical records including age, sex, stage of disease, academic level of father, clinical presentation, supporting examination such as biopsy, bone marrow aspiration, vanillymandelic acid (VMA), lactic dehydrogenase (LDH), ferritin, and outcome. The outcome was grouped into alive, death, and lost to follow up.
Results : One out of 50 was excluded. Forty (81.6%) patients had stage IV disease, 2 (0.4%) patients had stage II/III disease, and 7 (14.2%) patients had stage IVS disease. Eight (16.3%) patients, 32 (65.4%) patients, 6 patients (12.2%), and 3 (6.1%) patient were diagnosed under one year old, 1-<5 years old, 5-<10 years old, more than 10 years old, respectively. Male to female ratio was 1.3:1. Twenty eight (57.1%) patients had father with academic level under junior high school. Abdominal complaint (28.5%) and proptosis (22.4%) were the most common chief complaints of patients. Eleven (22.4%) patients were alive at the end of observation, 17 (34.7%) were dead, and 21 (42.9%) were lost to follow up. The most common cause of death was sepsis.
Conclusions : Most patients came with stage IV disease. High number of lost to follow up should be noticed. Most patients ended in palliative care.
Keywords: neuroblastoma pediatric clinical profile outcome