Abstract Ref Number = APCP882
CLINICAL CASE REPORT MALARIAL HEPATOPATHY IN 10 YEARS OLD BOY
Elsa Ameliana,Marito W Logor,Irma R Ratu
Yowari General Hospital
Background : Jaundice in severe malaria may occured by several causes including malarial hepatopathy. Malarial hepatopathy is a condition where the hepatocytic dysfunction appear with no sign of liver parenchym inflammation, characterized by elevated transaminase enzymes of up to more than 3 times the normal level in P. falciparum alone or a mixed infections. Children who lived in endemic areas and reccurent exposed to malaria had V?2+ T cells that progressively lost, became dysfunction and contribute to clinical imunity in re-exposed infection in the future.
Case Presentation Summary : Here we report a 10-year-old male child who live in Sentani, Jayapura, Papua, presented with features of malarial hepatopathy. We obtained the diagnosis from clinical, physical, laboratory and ultrasound examination. From examination, patient complaint of high grade fever, had history of malarial hepatopathy 1 year ago, discoloration of sclera and hepatomegaly. Investigation revealed P. Falcifarum from blood film, elevated transaminase enzymes with no abnormality of liver in ultrasound examination. Patient received IV artesunate and showed clinical improvement.
Learning Points/Discussion : Patients with malarial hepatopathy are more prone to complication, hence it should be promptly recognized and start therapy with antimalarial immediately, because hepatic dysfunction is reversible and respond favorably to antimalarial therapy. Awareness of this condition, will affect the outcome of patients with malarial hepatopathy.
Keywords: Malaria Malarial Hepatopathy Reccurent Malaria Infection Reccurent Malarial Hepatopathy