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Abstract Ref Number = APCP774
Poster Presentation
SERUM NT-PROBNP IN CHILDREN WITH VARIOUS LEFT TO RIGHT SHUNT CONGENITAL HEART DISEASE
Wisvici Yosua Samin,Indah Kartika Murni,Endy Paryanto Prawirohartono Department of child health Faculty of medicine public health and medicine Universitas Gadjah Mada
Background : N Terminal pro B-Type Natriuretic (NT-proBNP) levels are elevated in children with left to right shunt (LtR) congenital heart disease (CHD). However, the benefit of this biomarker as a diagnostic tool of heart failure or pulmonary hypertension in congenital heart disease is still need further investigation. As far as we know, reports in the literatures about benefit of NT-proBNP as a cardiac biomarker in pediatric cardiology are scarce. The aim of this study is to compare the NT-proBNP levels among various types of LtR CHD Material : We conducted a cross sectional study involving 39 children (23 males 16 females) who admitted to pediatric cardiology clinic of the Dr. Sardjito Hospital in May 2018. There were 5 types of defect, i.e. atrial septal defect(ASD), ventricular septal defect (VSD), patent ductus arteriosus (PDA), combined ASD and PDA, and combined ASD and VSD based on echocardiography. The NT-proBNP levels were measured using electrochemiluminescence immunoassay at the recruitment day Results : There were 20 (51%) children presenting with VSD, whereas PDA, ASD, combined ASD and PDA, and combined ASD and VSD were 10(27%), 6(15%), 2(5%), and 1(2%) respectively. The median (interquartile range) of NT-proBNP in all subjects was 342.9 (153.1-731.2)pg/dl. Among children with LtR shunt the highest levels of NT-proBNP was found among PDA 550.6 (329.3-2195) pg/dl and ASD 321.5 (169.8-1069.7)pg/dl followed by VSD 257.6 (165-356)pg/dl. Compared to normal levels in children of particular age, the NTproBNP levels among LtR shunt CHD were higher Conclusions : NT-proBNP levels in children presenting with LtR shunt congenital heart defects are higher than normal children of particular age. Further investigation is needed to evaluate the benefit of NT-proBNP as a biomarker for LtR shunt CHD in childrenv
Keywords: NT-proBNP left to right shunt congenital heart disease
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