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Abstract Ref Number = APCP70
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Pesticide exposure as an endocrine-chemical disrupting in children
Agustini Utari Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
In the last two decades, there is a scientific concern about the chemicals that effect the endocrine system, called endocrine-disrupting chemicals (EDC). Several groups of chemicals have potential actions as EDCs such as pesticides, plastic and plasticizers, industrial chemicals and many other chemicals that are widespread use. In the agricultural area, particularly in developing countries, the pesticide exposure is one of the big concern. The severity and toxicity of pesticides exposure may be higher since the regulatory and information is limited. Unfortunately, children are considerably more vulnerable to the pesticide exposure compared to adult since the greater intake of food or fluids per body weight and frequent hand-to-mouth activity. The acute toxicity has been known from organophosphate pesticide, however, the chronic health effects of pesticide exposure need more attention because the implication of nonacute exposure relatively low but combined exposures encountered routinely by children. In our study, the risk of pesticide as EDCs posed by the increased risk of having hypothyroidism in children with a history of pesticide exposure. This finding was in line with previous studies about the thyroid disturbance caused by environmental exposure including pesticide. It is still debatable, whether some EDCs may interfere with the thyroid function through affecting thyroid development, development of anti-thyroid antibodies or by interaction with other substance. However, in the clinical perspective, clinicians should be made aware of the potential risks of the pesticide exposures an EDC.
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