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Abstract Ref Number = APCP59
Invited Speakers
Appropriate ventilation management to prevent brain injury in premature infants
Philip Henschke Mercy Hospital for Women Melbourne, Australia
Compared to children born at term, children born preterm have higher rates of cerebral palsy, sensory deficits, and learning difficulties. Reducing levels of brain injury and resulting disability is an essential step in improving long-term health and well-being in this patient population. Activation of systemic inflammatory pathways and hemodynamic instability in the newborn period play a critical role in the pathogenesis of brain injury in preterm infants. Evidence is now emerging to indicate that ventilation-induced lung injury can initiate a systemic inflammatory response. This systemic inflammatory response may contribute to cerebral blood flow instability, which in turn may trigger events that escalate risks of cerebral injury. Further, prolonged periods of hypocarbia associated with use of excessive tidal volumes may contribute to cerebral blood flow insufficiency. This presentation will focus on ventilation strategies that aim to limit resulting systemic inflammatory response and associated cerebrovascular instability that may contribute to the development of brain injury in premature infants.
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