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Abstract Ref Number = APCP426
Oral Presentation
CORRELATION BETWEEN THE HOMEOSTASIS MODEL ASSESMENT FOR INSULIN RESISTANCE (HOMA-IR) LEVELS AND VITAMIN D IN OBESE ADOLESCENTS
yulia dewi,I Made arimbawa RSUP Sanglah Denpasar Bali
Background : Obesity is a pathological condition characterized by the excessive acumulation of fat in the body. Obesity during adolescence can developed into obesity in adulthood and will increase the risk of metabolic dissease sush as insulin resistance. Recent years the role of vitamin D begin to be connection with insulin resistance. Vitamin D plays a role in regulation of synthesis dan insulin secretions from pancreatic beta cells, increase peripheral and hepatic glucose uptake. In obesity there is decrease in vitamin D bioavailability that causes low levels of vitamin D. This causes an increased risk of insulin resistance in obesity. This study aimed to proves a correlation between insulin resistance and vitamin D levels in adolescents with obesity.
Material : A observational analytic research with crossestional design has been done in junior and senior high school in Denpasar. Adolescennts performed anthropometric screening covers weight, height, body mass index (BMI), obesity if BMI > 95th percentile of CDC 2000 curve. Examined vitamin D levels and insulin resistance through calculation of HOMA-IR levels. Sample size calculation with ? 0,05, correlation coefficient (r) set to 0,5 with minimum sampel size 50. Statistic was done on SPSS though analysis of normality dan correlation test to get r value.
Results : In this sudy, average of vitamin D levels is 18,96 ng/mL. 10 (20 %) classified as vitamin D insufficiency and 39 (79 %) vitamin D deficiencies. The average of HOMA-IR levels 3,84, 24 (48 %) with insulin resistance based on HOMA-IR levels. Correlation coefficient between HOMA-IR levels and vitamin D was obtained – 0,4.
Conclusions : Conclusion: Incidence rate of insulin resistance in obese adolescent in Denpasar is 48 %. There is a moderate negative correlation between HOMA-IR levels and vitamin D in obese adolescents.
Keywords: obese adolescent insulin resistance vitamin D
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