...
Abstract Ref Number = APCP425
Oral Presentation
THE THREE-YEARS SURVIVAL RATE AMONG DOWN’S SYNDROME CHILDREN IN SARDJITO GENERAL HOSPITAL
TIona Romauli,Suryono Yudha Patria,Setya Wandita Department of Child Health RSUP Dr Sardjito Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada Sardjito General Hospital, Yogyakarta, Indonesia Department of Child Health RSUP Dr Sardjito Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada Sardjito General Hospital, Yogyakarta, Indonesia
Background : Down’s syndrome (DS) is the most common congenital chromosomal anomaly and occurs in about 1:700 live birth globally. Reports stated an increasing survival rate because of advance medical and surgical care. The highest mortality in DS takes place in the first three years of life with its comorbidities are congenital heart disease, gastrointestinal defect and hypothyroidism. Currently, survival rate in Indonesia is still unknown, therefore we examined three-years survival rate among children with DS in Sardjito General Hospital.
Material : We included all medical records with DS children, diagnosed based on clinical judgment or chromosomal analysis, in Sardjito General Hospital during 2013 to 2014. We excluded medical records with inadequate data. Survival rate was analysed using Kaplan-Meier curve for three years.
Results : The 1-year, 2-years and 3-years survival rate in Down’s syndrome children were 81.6%, 76.3 %, and 75.0 % respectively. Three years survival with heart defect was 66.7 % (50/75) and without was 83.1 % (64/78)(p=0.042). Furthermore, three years survival with gastrointestinal defect was 52.9 % (18/34) and without was 80.7 % (96/119) (p<0.005). The most common cause of death was sepsis and septic shock (48.6%, 19/38 patients) followed by pneumonia (13.2%, 5/38 patients), and acute respiratory distress syndrome (13.2%, 5/38 patients).
Conclusions : The survival rate in Sardjito General Hospital is still lower compared to other developed countries. This may be caused by the lack of antenatal diagnosis of Down’s syndrome and comprehensive management of patient. Further research is needed to analyse the cause.
Keywords: Down's syndrome mortality survival rate comorbid
Disclaimer: The Views and opinions expressed in the articles are of the authors and not of the journal.
Editor-In-Chief
Journal Office
Mid City Hospital, 3-A Shadman II
Jail Road, Lahore ,Pakistan
Associate Editor
Dr. Muhammad Faheem Afzal
Support & Help
e-Journal Administrator
Dr. Khalid Masud
Administrator