Abstract Ref Number = APCP421
Oral Presentation
Ketut Dewi Kumara Wati,Anak Agung Sagung Sawitri,Putu Diah Vedaswari,I Wayan Eka Satriawibawa,Meita Dhamayanti,Budi Setiabudiawan,Ida Parwati Doctoral Program Faculty of Medicine Universitas Padjadjaran Bandung Inodnesia Department of Public Health and Preventive Medicine Faculty of Medicine Udayana University Denpasar, Bali, Indonesia Department of Child Health, Faculty of Medicine, Udayana UniversitySanglah Hospital Denpasar, Bali, Indonesia Department of Child Health Dr Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia Department of Clinical Pathology and Laboratory Medicine, Dr Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Background : Long-term observation on the reversibility of stunting in children with HIV is limited. We sought to determine reversibility of the height for age z score at 24 and 60 months(HAZ 24 and HAZ60) observation, and correlation of HAZ24 and HAZ60 with earlier HAZ.
Material : A part of longitudinal study on the linear growth of children with HIV. Subjects were a 177 cohort, attended Central Hospital in Bali, Indonesia between 2009 and 2018. Inclusions were aged <14 years-old, started HAART and have repeated height measurement at 3-6 months for at least one year. Exclusions were aged <1 month and incomplete data. Height data were transferred into HAZ using WHO anthro macros. We determine stunted reversibility as HAZ24 and HAZ60 >-2SD, respectively and analyze correlation of HAZ24 with HAZ 6, 12 and 18 months while HAZ60 was analyzed to HAZ 36,42 and 48, with Spearman correlation or X2 test using STATA 15.0 version, significance P<0.05.
Results : There were 71.02%, 52.83%, and 46.67% stunted children, at diagnosis, 24 and 60 months observation. There were 127 subjects at six months; median age was 33 months, 61.02% were male, median HAZ was -2.36, IQR 2.19 min -5.5 max 3.11. At 24 months, median HAZ was - 2.185, IQR 1.93, min -4.54, max 2.13. The correlation coefficient (“r”) between HAZ 24 to HAZ 6, 12 and 18 months were 0.72, 0.79, 0.87, respectively. At 60 months, median HAZ was -1.81, IQR 1.73, min -5.94, max .27 with “r “ were 0.83, 0.87, 0.96, 0.97 between HAZ 60 and HAZ36, 42, 48, and 54 months. As much as 27.9%, 24.2% and 14% stunted children at 6, 12 and 18 months reversed at 24 months, which lower percentage at 60 months. All P<0.001.
Conclusions : Reversibility of stunting at 24 and 60 months in our total cohort are low.
Keywords: reversibility of stunting children with HIV HAART
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