Abstract Ref Number = APCP406
VITAMIN D LEVEL & TUBERCULIN CONVERSION AMONG UNDERFIVE CHILDREN WITH TB CONTACT HISTORY AFTER VITAMIN D SUPPLEMENTATION
Finny Fitry Yani,Fitrisia Amelin,Hamdi ,Roza Erisma,Darfioes Basir,Lola Lusita,Nur Indrawaty Lipoeto,Eryati Darwin,Bambang Supriyatno
Department of Child Health Faculty of Medicine Universitas Andalas MDjamil Hospital Department of Nutrition Faculty of Medicine Universitas Andalas Department of Histology Faculty of Medicine Universitas Andalas Department of Child Health Faculty of Medicine Universitas Indonesia Cipto Mangunkusumo Hospital
Background : Vitamin D status is associated with developing of tuberculosis infection especially in under-five children. We will describe vitamin D level and tuberculin conversion with TB contact history after vitamin D supplementation in children with TB contact history.
Material : During March 2014-December 2015, we were performed a double blind randomized study to 66 children underfive with TB contact history, but healthy condition regarding to tuberculin skin test results.We gave twice single high dose (25.000 IU) vitamin D3 and placebo randomized alocation, at baseline and day 42, then follow up until 12 weeks. Tuberculin conversion was determined using tuberculin skin test, with positive diameter ? 10 mm after 72 hours. We examined vitamin D serum level by ELISA methods.
Results : Before intervention mean of vitamin D level at intervention group less than placebo (24.33 + 7.5 vs 26.94 +8.61). After intervention the mean of vitamin D level at intervention group more higher than placebo (28.47 + 7.18 vs 27.67 + 9.02), but not significantly differences. Among 8 (12.1%) children with TST conversion, we found that at baseline no subject with sufficient vitamin D status, and after vitamin D supplementation there were 3 subject with sufficient vitamin D status at intervention group.
Conclusions : We demonstrated that there were increase of mean vitamin D level after vitamin D supplementation, but neverthelees TST conversion remains occur
Keywords: vitamin D level tuberculin conversion TB contact history