PROGNOSTIC VALUE OF IL-10 IN CHILDREN WITH SEPTIC SHOCK
Rahmi Meitia Ambon,Idham Jaya Ganda,St Aizah Lawang,Dasril Daud,Aidah Juliaty A Baso,Nadirah Rasyid Ridha
Dept Ilmu Kesehatan Anak FK UNHAS
Background : Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Five to 30% of pediatric patients with sepsis will develop septic shock with mortality rates of 20–30%. As an anti-inflammatory cytokine, IL-10 help abate and modulate an up-regulated immune response bringing it back to homeostasis after the threat has been eliminated. Nevertheless, in septic shock, immune suppression caused by the excessive production of IL-10 appears to persist and has been associated with high mortality. This study aimed to identify IL-10 as an outcome predictor (survival/non-survival) in children with septic shock.
Material : This prospective cohort study was conducted in Pediatric Intensive Care Unit Wahidin Sudirohusodo hospital from December 2016-Mei 2017. A total of 70 sepsis patients were included. The plasma specimens of IL-10 examination were collected when the patients were diagnosed, they were then monitored until the outcomes achieved (survival/non-survival). The septic shock diagnosis used the criterion of the International Pediatric Sepsis Consensus 2005. IL-10 serum was measured using the technique of the Enzyme Linked Immunosorbent Assay.
Results : The level of serum IL-10 was significantly higher in non-survival group. Cut off point ? 211 pg/mL was obtained through the ROC, with sensitivity 94.5%, specificity 78.7%, positive predictive value 83.3%, negative predictive value 92.8%, odds ratio 65.0 (CI 95 % 12.46 - 338.91).
Conclusions : IL-10 level can be used as an outcome predictor of children with septic shock, and limit level ? 211 pg/mL is the most optimal cut off point as a prognostic value.
Keywords: IL-10 Septic shock Predictor
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