Abstract Ref Number = APCP36
Gut Brain Axis Paradigm in Child Development:
Future Insight in Child Development
I Gusti Ayu Trisna Windiani
Child Health Department, Sanglah General Hospital, Udayana University
In early age gut health is important determiner of child’s growth and development. Gut roles to monitor and integrate gut functions as well as link to central nervous system, which is known as gut brain axis (GBA). Gut brain axis is a bidirectional communication, linking emotional and cognitive centers of brain with peripheral intestinal functions, through an array of neural, endocrine, and immune signaling pathway. Human microbial colonization begins at birth and continues to develop and modulate in species abundance for about 3 years, until the microbiota become adult-like. Recent advances implicate that critical periods of brain development occur overlap with periods of microbiota colonization in gastrointestinal tract, and changes in one condition appear to effect each other.
Early life perturbations of developing gut microbiota can impact neurodevelopment and potentially adverse mental health outcomes later in life. Most of the researches were originated mainly from animal, in vitro and in vivo studies such as germ-free animals, probiotics, antibiotics to study the role of microbiota in based modulating GBA since studies about effect of microbiota on GBA in human are still limited. Those intriguing preclinical results underline the importance of human clinical studies in future. Researches showed colonization of microbiota in early childhood is important to determine the development of brain, behavior, learning process, obesity and autism. The concepts of parallel and interacting microbial-neural critical widening future insight for developing novel microbiota-modulating therapeutic strategies in early life to combat neurodevelopmental deficits and brain disorders
Keywords: gut brain axis, child, development, intestinal, microbiota