Differences in the Prevalence of Hypomagnesemia in Childhood Epilepsy with and without Seizures Controlled
Tumpal Rajagukguk,Yazid Dimyati,Rizky Adriansyah,Johannes Harlan Saing,Cynthea Prima Destariani
Departemen Child Health Faculty of Medicine University of Sumatera Utara Medan Indonesia
Background : Several studies had been reported the prevalence of hypomagnesemia in childhood epilepsy. In Indonesia, there was no study reported about hypomagnesemia in childhood epilepsy.
Material : Cross-sectional study was conducted in March-April 2018 in the Neuropediatric outpatient clinic of H.Adam Malik General Hospital. Inclusion criteria were children between 7 months to 18 years old who have been receiving anti-epilepsy drugs (AED) at least 6 months. Pediatric patients suffering from chronic diarrhea, kidney failure, hypothyroidism, malnutrition, and being treated for hemodialysis or chemotherapy are excluded. Magnesium levels of blood samples were examined in the clinical pathology laboratory of H.Adam Malik General Hospital. Analyze data using Chi square and calculate the prevalence ratio (PR).
Results : Of 72 children with mean age for controlled seizures 6.9 years and 9.5 years in uncontrolled seizures. From 9 patients with hypomagnesemia (<1.8 mg/dL), all the patient had uncontrolled seizures (PR = 2.3, CI 1.75-3.10, P = 0.001). Hypomagnesemia was present in 7 of 32 children with duration of AED ?2 years (PR = 4.3, CI 0.97-19.62, P = 0.031).
Conclusions : There is a difference in the prevalence of hypomagnesemia in childhood epilepsy with and without seizures controlled. All the patient with hypomagnesemia showed uncontrolled seizures. The duration of AED ? 2 years has a risk of hypomagnesemia about 4.3 times
Keywords: hypomagnesemia epilepsy seizures child
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