SURVIVAL ANALYSIS OF STEROID-RESISTANT NEPHROTIC SYNDROME (SRNS) IN PEDIATRIC
Nindy Resti Rahayu,Ratih Kusumawardani,Anita Febriana,Astrid Kristina Kardani,Krisni Subandiyah
Paediatric Department Medical Faculty of Brawijaya University Saiful Anwar General Hospital Malang East Java Indonesia Nephrology Division Paediatric Department, Medical Faculty of Brawijaya University, Saiful Anwar General Hospital Malang, East Java, Indonesia
Background : Children with prolonged, uncontrolled steroid-resistant nephrotic syndrome (SRNS) often experience significant morbidity and may require hospitalization or long-term outpatient therapy while waiting for a treatment response. Pulse methylprednisolone therapy (PMT) and cyclophosphamide (CSA) has been described as a successful treatment for SNRS but there is no data survival rate for children with SRNS to evaluate outcome of their treatment.
Material : Ten children with SRNS were enrolled and divided into two groups based on their treatment: CSA or PMT. They are seven boys and three girls aged 1-12 years old. For outcome of the treatment we observe proteinuria’s patient since the first month until six months of protocol therapy. Data is analyzed to apply statistical methods Survival Analysis in STATA 9.2 (license) using Kaplan-Meier analysis. Kaplan-Meier estimate is one of the best options to be used to measure the fraction of subjects living for a certain amount of time after treatment.
Results : Kaplan–Meier analysis revealed that only 30% of patients who treated using CSA protocol spend 4 months of treatment with none proteinuria while 50% of patients who treated using PMT are more shorter period of treatment 3 months with none proteinuria.
Conclusions : Patient with PMT have shorter time to get remission than CSA.