Abstract Ref Number = APCP275
Value of Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) to Predicts End Stage Renal Disease or Death Event in Pediatric CAKUT
Oke Rina Ramayani,Rosmayanti Syafriani Siregar,Rafita Ramayati,Kiking Ritarwan,Putri Chairani Eyanoer
Pediatric Department University of Sumatera Utara Neurology Department University of Sumatera Utara Public Health Department University of Sumatera Utara
Background : In recent years, urine NGAL has become a biomarker which has been demonstrated to be associated with poor prognosis of chronic kidney diseases (CKD). The prevalence of CKD has risen rapidly in worldwide due to congenital anomalies of the kidney and urinary tract (CAKUT). The aim of this study was to analyzed urine NGAL on long term CKD (end stage or death) in patients CAKUT.
Material : This is an observational, case and control study, involving 120 patients with CAKUT, who were divided into two groups: the obstructive type and non obstructive type. All patients were followed for at least 4 years. Detailed history of CAKUT and symptoms pointing to these diagnoses was obtained. Urinalysis, culture urine, urine NGAL and imaging studies (MCU and renal ultrasound) were performed for all of participants. Primary end point was a composite one that consisted of recurrent urinary tract infection, metabolic acidosis. Secondary end points included ESRD or death.
Results : The mean age of the patients was 7.5 ± 3.1 years and 60% were boys. Sixty two percents of patients had obstructive diagnosed of CAKUT. In bivariate analysis there was strong association between type of CAKUT and urine NGAL also proteinuria. Those with obstructive type will 6.06 times higher to experience poor prognosis while those with high NGAL would be 12.5 times higher.
Conclusions : Urin NGAL and type of CAKUT were found significantly associated with CAKUT children who had progressively to ESRD. Therefore, we suggest that urin NGAL could be considered in predicted ESRD/death in CAKUT patients
Keywords: Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL), End Stage Renal Disease CAKUT