Abstract Ref Number = APCP258
NEUTROPHIL TO LIMPHOCYTE COUNT RATIO AS A RISK FACTOR FOR BLOOD STREAM INFECTION IN PEDIATRIC WARD RSUP SANGLAH DENPASAR
I MADE YULLYANTARA SAPUTRA,I WAYAN GUSTAWAN,MADE GEDE DWILINGGA UTAMA,BNP ARHANA
Residency Program Department of Child Health Sanglah General Hospital Udayana University Supervisor Department of Child Health
Background : The neutrophil lymphocyte count ratio (NLCR) is a potentially interesting parameter in predicting bacteremia in patients admitted with suspected community-acquired infections. The incidence of bacteremia, defined as the presence of viable bacteria in the bloodstream, in patients who were being admitted to hospital, is approximately 1%. The mortality rate is 25%–30%, increases to 50% when associated with severe sepsis. The objective of this study is to investigate whether ratio neutrophil and lymphocyte is associated with the development of blood stream infection.
Material : This was a hospital-based case-control study, review of the medical record from January 2016 until March 2018. We analyze the association between ratio neutrophil and lymphocyte to blood stream infection.
Results : Between January 1st 2016 and March 31st 2018, there were 98 patients with positive blood cultures and 100 negative blood cultures. There were total 116 male (58,5%) and 82 female (40,9%) subjects. In the control group, there were 66 (66.7%) male and 33 (33.3%) female subjects, while in the case group there were 50 (51%) male and 48 (49%) female subjects. The median age for case group was 12 months while the median age for control group was 24 months. From the ROC curve, the optimal cutoff value for NLCR was determined as 5.44. The OD ratio determined the relationship between neutrophil and lymphocyte count (NLCR) to blood stream infection was 2.87 with 95% CI (1,52-5,42). The adjusted odd ratio was 3,12 with 95% CI (1,608-6,059).
Conclusions : The NCLR ratio ?5,44 is a risk factor for developed blood stream infection. This result can be used as a cut off point to initially administered antibiotic to prevent the worse prognosis (sepsis, multiple organ failure, and death).
Keywords: RISK FACTOR RATIO NEUTROPHILE AND LYMPHOCYTE BLOOD STREAM INFECTION