Abstract Ref Number = APCP257
THE RELATIONSHIP BETWEEN URINARY ALBUMIN TO CREATININE RATIO AND MORTALITY IN CHILDREN WITH SEPSIS
Galih Ranggana,Valentina Lini Gunawan,Jose M Mandei,Ari L Runtunuwu,Max FJ Mantik
Sam Ratulangi university Sam Ratulangi University
Background : Sepsis is the most common cause of death in infants and children worldwide. Not only health issues, but also a worldwide socioeconomic challenge, where sepsis decreases quality of life and significantly increases mortality. The aim of this study was determine the relationship between urinary albumin & creatinine ratio with length of stays in children.
Material : This study was carryout using an observational analytic study method with a prospective cohort approach in all children sepsis cases that being treated since October – December 2017 on Prof. R.D. Kandou Public Hospital with the inclusion criteria: 1 month to age 72 months, meet sepsis criteria, parents sign the consent form. the exclusion criteria: obesity, poor nutrition, previous glomerulopathy history, hypertension, malignancy, DM, chronic kidney disease, trauma and postoperative failure of urine sample collection within 6 hours, then observed outcomes of patients who died or alive.
Results : From 41 chidren with sepsis, the youngest age was 1 month with the oldest age was 65 months. The sample consisted of 24 boys. Total sample who survived 21 children. The relationship between urinary albumin and creatinine ratio was tested with Spearman correlation coefficient analysis obtained rs = 0.940 with p <0.0001. Patients with length of stays > 7 days as many as 12 patient with higher albumin and creatinine ratio, while the number of patients with length of stay < 7 days as many as 9 patient with lower albumin and creatinine ratio. These results suggest a strong and significant association between urinary albumin and creatinine levels with length of stay.
Conclusions : The higher the urine albumin and creatinine ratio, the longer the length of stay of children with sepsis.
Keywords: albumin creatinine ratio sepsis mortality