Abstract Ref Number = APCP234
NEBULISED MAGNESIUM SULFATE IN ACUTE BRONCHIOLITIS:A RANDOMISED CONTROLLED TRIAL
Santosh T Soans,MounikaMotamarri, AshwathyRajan
Head of Department and Professor, AJ Institute of Medical Sciences, Mangalore
Junior Resident, AJ Institute of Medical Sciences, Mangalore, India
Assistant Professor, AJ Institute of Medical Sciences, Mangalore, India
Background:Primary objective of this study was to assess the efficiency of nebulized magnesium sulfate as a bronchodilator in hospitalized infants,to measure the length of hospital stay and to assess the improvement of respiratory distress assessment instrument score in children with acute bronchiolitis.
Methodology:Randomized clinical trial was conducted comprising of 60 childrenwith acute bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0.1 ml/kg). The primary outcome being length of hospital stay. The use of oxygen, temperature, oxygen saturation (SPO2), pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) scorewere measured in the beginning of the study and during hospitalization. Data analysis was done using a software SPSS version 17.0. the variables were compared and analyzed with chi square test, ANOVA test, t-test.
Results:The mean (SD) age of 60 infants was 5.1(±2.6) months and 60% were boys. The length of hospital stay was decreased in Group A (magnesium sulfate group) (P<0.01). The need for add-on therapy was 33% in magnesium group and 60% in epinephrine group(P<0.05). SPO2 and vital signs were similar in the two groups. Improvement in RDAI score was seen in magnesium sulfate group but was not significantly better in infants treated with nebulized epinephrine.
Conclusion:Study conducted revealed that in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate was comparable to nebulized epinephrine. However, the findings in the study suggest that inhaled magnesium sulfate is superior to inhaled epinephrine in terms of reducing the length of hospital stay and number of additional nebulization’s but did not prove its efficacy in reduction of the respiratory distress assessment index score in children with bronchiolitis.