CORRELATION BETWEEN ALLERGEN POLYSENSITIZATION AND SEVERITY OF ALLERGIC RHINITIS IN CHILDREN
Randy Renaldo Wiratara,Sumadiono ,Cahya Dewi Satria
Faculty of Medicine Gadjah Mada University Department of Child Health, dr Sardjito Hospital
Background : Allergen polysensitization is defined as positive IgE response against 2 or more allergens. Allergic rhinitis is one of allergy manifestation mediated by IgE. Whether severity of allergic rhinitis affected by the number of allergen sensitizations is still not clear.
Material : The study design was a cross sectional study of 80 children with allergic rhinitis aged 2-12 years at Yogyakarta in April-September 2014. We conducted skin prick test, and we defined the severity of allergic rhinitis using ARIA (Allergic Rhinitis and its Impact on Asthma) criteria. Statistical analysis using two-tailed Spearman test.
Results : From 80 subjects, there were 45 subjects (56.3%) had allergen polysensitization. 29 subjects (36.3%) had mild intermittent allergic rhinitis, 43 subjects (53.8%) had moderate-severe intermittent allergic rhinitis, 4 subjects (5%) had mild persistent allergic rhinitis, and 4 subjects (5%) had moderate-severe allergic rhinitis. There was no significant correlation between number of allergen sensitization and the severity of allergic rhinitis in children (p = 0.322).
Conclusions : Half of children with allergic rhinitis have allergen polysensitization. The number of allergen to which a child sensitized is not related to severity of allergic rhinitis.