Abstract Ref Number = APCP203
Assocation between vitamin D deficiency with Hypertension in Children with Systemic Lupus Erythematosus
Fransiska Gabrielis Wona Remi,Sumadiono ,Cahya Dewi Satria
Department of Child Health Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada dr Sardjito General Hospital Yogyakarta Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaDr Sardjito General Hospital, Yogyakarta
Background : Vitamin D deficiency is highly prevalence in systemic lupus erythematosus (SLE) patients due to the disease itself, photosensitivity, renal insufficiency and use of medications. Previous studies suggested that low concentration of 25-hydroxyvitamin D3 were associated with a higher risk of hypertension. However, the effect of vitamin D deficiency on hypertension in SLE patients has not been studied yet. This study aimed to determine the association between vitamin D consentration and hypertension in pediatric SLE patients
Material : We conducted a cross sectional study involved 62 childrens who were diagnosed with SLE in Dr. Sardjito General Hospital Yogyakarta. Our subjects were children aged 5 to 18 years who received SLE therapy protocol from Januari 2014 - April 2018. Vitamin D deficiency was defined as the consentration level of 25-hydroxyvitamin D3 < 20 ng/ml. The association between 25-hydroxyvitamin D3 concentrations and hypertension was analyzed using univariate and multivariate logistic regression adjusting for several variables including disease activity, steroid therapy, obesity, dyslipidemia, and renal function.
Results : Most of our subjects were female (93.5%) with mean of age 14.6 ± 3.1 years. The prevalence of vitamin D deficiency was 66%. Hypertension observed in 51.2% of patients with vitamin D deficiency and 66.7 % in non deficiency patients. Logistic regression analysis found that no significant association between vitamin D deficiency and hypertension (OR 2.4, 95% CI 0.81 – 7.19, p = 0.115).
Conclusions : Lower serum 25-hydroxyvitamin D3 concentrations had no association with hypertension in SLE patients
Keywords: systemic lupus erythematosus vitamin D hypertension