Abstract Ref Number = APCP176
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SKIN ALLERGY IN CHILDREN (Focus on Atopic Dermatitis)
Zakiudin Munasir Department of Pediatrics, Faculty of Medicine Universitas Indonesia Dr CiptoMangunkusumo
The skin barrier defect results in some skin allergies like Atopic Dermatitis (AD), urtikaria and angioedema and contact dermatitis. In this presentation will be focused on AD because AD is the most common skin allergy in children. AD is a common, chronic inflammatory skin condition characterized by pruritus, typical morphology and distribution, periodic recurrences, and association with other atopic disease (such as asthma, allergic rhinitis). It is Influenced by immune dysregulation, but an impaired skin barrier associated with mutation in filaggrin may be a central pathogenetic factor. The atopic march proposes that AD is a gateway disorder: the impaired skin barrier results in epicutaneous sensitization and can then engender other atopic diseases such as asthma and allergic rhinitis. The etiopathophysiology is : Genetic background , dry skin / defective barrier, microbial colonization ,autonomic nervous system dysregulation ,psychosomatic interaction,inflammation,non-immune (irritant),allergic DTH (TH1),allergic atopic (TH2, IgE),autoimmune (IgE against epidermal proteins) . The management of AD include: Avoidance strategies,basic skin care (emollients, oil baths),antipruriginous (wet wraps, antihistamines),antiinflammatory (steroids, UV, topical immunomodulators),antimicrobial (colourings, antiseptics, antibiotics)and psychosomatic counselling . Skin care is very important in longterm management in AD and other skin allergy diseases..
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