Abstract Ref Number = APCP1205
SIDE EFFECT OF SHORTER REGIMEN IN MDR TB IN ADOLESCENT A CASE REPORT
Intan Robiah,MS Anam,Dwi Wastoro Dadiyanto,Magdalena Sidhartani
Department of Pediatrics Faculty of Medicine Diponegoro University Department of Pediatrics, Faculty of Medicine, Diponegoro University Dr Kariadi Hospital
Background : WHO treatment guidelines update in 2016 for drug-resistant tuberculosis is using shorter regimen. A shorter MDR-TB regimen refers to a course of treatment for RR-TB or MDR-TB lasting 9–12 months, which is largely standardized, and whose composition and duration follow closely.
Case Presentation Summary : A case of MDR-TB in a 15 years old girl was reported. This is a first MDR-TB case using shorter regimen treatment in Dr. Kariadi Hospital. Her father is also receiving MDR-TB treatment. Previously, patient has been treated with first line OAT for 2 months but the treatment was stopped because of poor respond and gene expert examination result was MTB detected with Rifampicin resistance. This patient was fit for shorter regimen treatment including Kanamycin injection, HZE, Moxifloxacin, Etionamid, Clofazimin, and was administered for 5 months in this case. The side effect of the treatment including athralgia and elevation of uric acid 10.4 mg/dl on second months which was treated with Allopurinol 100mg three times a day. On the fifth months follow up showed no athralgia and decreased uric acid level into 5.0 mg/dl. Tinnitus was appeared on fourth months therapy and still needed follow up during injection. The culture conversion was achieved on the third months treatment. Now the patient was still on the fifth month therapy and shown a good respond to the treatment.
Learning Points/Discussion : Although there was side effect that occurred in shorter regimen treatment but it gave a good response to the therapy. It is not an obstacle to treat MDR-TB patient with shorter regimen therapy. With good monitoring and therapy, side effect can be reduced.
Keywords: multidrug-resistant tuberculosis Children regiment