Ensuring safe drug administration in pediatric
patients with renal dysfunctiopatients
Ryoko Harada,Riku Hamada
Department of Nephrology, Tokyo Metropolitan Childrens Medical Center
Division of Nephrology and Rheumatology, National Center for Child Health and Development
Medication errors could happen to all patients on medication. Medication errors are especially common in pediatric patients. It is reported that 5% to 27% of all pediatric medication orders result in a medication error. Medication for pediatric patients tends to be complicate because they need to be adjusted by age and weight. In patients with renal dysfunction, their medication also need to adjust the appropriatedosage according to their renal function, therefore the risk of medication error is high.
Adverse drug events resulting from medication errors can be preventable.In order to prevent medication errors in children with renal dysfunction, recognition of nephrotoxic drugs and renally excretory drugs, as well as recognition of the standard value of serum creatinine(Cr) reference levels in children are necessary.When we use these drugs for the patients with renal dysfunction, renally excreted drugs need dose adjustment and nephrotoxic drugs should be avoided. In addition,in pediatric patients, due to variations in baseline Cr reference values, renal dysfunctions sometimes go unnoticed.
We conducteda study to explore the perception of nephrotoxic drugs, renally excretory drugs and children’s Cr reference values of physicians and pharmacists (Harada et al. ClinExpNephrol. 2018). According to our research results, the recognition of nephrotoxic drugs and renally excretory drugs by physicianwas low, and the recognition of Cr criteria for children in pharmacists was also low. To ensure safe drug administration, communication between physicians and pharmacists is paramount. There is an urgent need for the creation of a safe drug administration protocol for pediatric patients with renal dysfunction.
Disclaimer: The Views and opinions expressed in the articles are of the authors and not of the journal.
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