Abstract Ref Number = APCP1179
FACTORS ASSOCIATED WITH VITAMIN D DEFICIENCY IN PEDIATRIC INTENSIVE CARE UNIT PATIENTS IN MOHAMMAD HOESIN HOSPITAL PALEMBANG
Laurentsia ,Ratna Setia Asih,Desti Handayani,Silvia Triratna
Departemen of Child Health Faculty of Medicine Sriwijaya University Mohammad Hoesin Palembang Department of Child Health Faculty of Medicine Sriwijaya University Mohammad Hoesin Hospital Palembang
Background : Vitamin D deficiency (VDD) is common in children with critical illness and is associated with higher illness severity and death, length of stay (LOS) or duration of mechanical ventilation. Age, gender, nutritional status, and infection may predispose VDD. The aim of this study is to identify factors associated with vitamin D deficiency in children admitted to Pediatric Intensive Care Unit of Mohammad Hoesin Hospital.
Material : All patients aged 1 month to 18 years admitted to the PICU in Mohammad Hoesin Palembang who had vitamin D level measured within 24 hours of admission were included in this retrospective study between December 2017 and February 2018. Association between vitamin D status with several clinical factors was analyzed. Vitamin D was categorized as sufficient (?30 ng/ml), insufficient (20-30ng/ml), and deficient (<20 ng/ml).
Results : Thirty patients were included in this study with age range 50.5±10.5 months old and mean weight 15.5±2.2 kilograms. Eighteen (60%) were boys and 13 (43.3%) were undernourished. Mean level of Vitamin D was 20.7±1.5 ng/ml, 18 (60%) patients can be classified as deficient, 8(26.6%) insufficient, and 4(13.3%) normal. Patient with meningoencephalitis had a significantly lower level vitamin D (6.7ng/ml). The underlying illness in patients with VDD were mostly infections of CNS on 7 (23.3%), followed by respiratory tract infection in 6 (20%), and dengue infection in 4 (13.3%). No significant association was found between deficiency vitamin D and gender, nutritional status, however there was a significantly higher proportion of VDD found on children ?12 months (p=0.041). There were no associations between VDD with length of PICU stay, need for inotropes, need for mechanical ventilation, and mortality.
Conclusions : Incidence of VDD in PICU patients is high, and is associated with younger age (12 months). Most patients have infection as the underlying disease.
Keywords: vitamin D vitamin D deficiency pediatric intensive care unit