Abstract Ref Number = APCP1137
CORRELATION BETWEEN VITAMIN D AND LIPID PROFILE AMONG CHILDREN WITH BETA THALASSEMIA MAJOR
Christian Nasir,Nelly Rosdiana,Aridamuriany Dwiputri Lubis
Department of Child Health Faculty of Medicine Universitas Sumatera Utara Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara
Background : Beta thalassemia major is associated with lipid profile abnormalities, presented as lower level of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and higher triglyceride level; increasing risk for cardiovascular complications. The previous studies indicate that Vitamin D give positive impact on lipid profile in healthy children population. However, its role need to be determined in high risk group of children with beta thalassemia major. The objective of this study is to determine correlation between vitamin D (25-OHD) and lipid profile among children with beta thalassemia major.
Material : A cross-sectional study was conducted in a general tertiary hospital in Medan, Sumatera Utara, Indonesia from January to March 2018. Subjects were children aged below 18 year-old with beta thalassemia major. The measurement of vitamin D (25-OHD) level and 10-12 hour overnight fasting serum lipid profile including total cholesterol, triglyceride, HDL, and LDL were performed. Analysis was done using Pearson’s correlation and Fisher test. P value < 0.05 was considered significant.
Results : Forty-five subjects were enrolled in this study, with serum ferritin level ranged from 1017 to 13372 ng/mL. The prevalence of vitamin D deficiency (25-OHD level less than 20 ng/mL) in this study was 40%, with mean value 20.6 (SD 5.3) ng/mL. The markers for cardiovascular risk were observed to be elevated, both in Atherogenic Index Plasma (0.32 +/- 0,25) and TC:HDL ratio (4.2 +/- 1,5). Statistic analysis revealed that Vitamin D had positive correlation with total cholesterol (r=0.302, p=0.044) and HDL (r= 0.297, p=0.048). There were no significant correlation between either vitamin D and triglyceride (p=0.305), or vitamin D and LDL (p=0.727).
Conclusions : Vitamin D correlated positively with total cholesterol and HDL in children with beta thalassemia major. Positive correlation to HDL indicated beneficial effect of vitamin D to reduce the risk of cardiovascular complication.
Keywords: Thalassemia beta major Lipid profile Vitamin D