Abstract Ref Number = APCP1114
BLOOD LEVELS OF 25-HYDROXYVITAMIN D IN EPILEPTIC CHILDREN WITH SINGLE AND MULTIPLE ANTIEPILEPTIC DRUGS THERAPY
Chasan Ismail,Iin Fatimah,Miriawati ,Bangkit Putrawan,Loysa Ladydi Hutagalung,Ratih Dwi Andini,Prastiya Indra Gunawan,Darto Saharso
Department of Child Health Faculty of Medicine Universitas Airlangga Dr Soetomo Hospital Surabaya Indonesia
Background : Long-term use of antiepileptic drugs (AED) is a significant risk factor for vitamin D deficiency in children with epilepsy. Differentiation effect between single and multiple AED is still unclear. The aim of our study is to compare the influence of AED treatment for 25-hydroxyvitamin D (25-OHD) levels between single and multiple AED.
Material : A cross-sectional study of 2-18 years old epileptic children with long-term AED (phenytoin, phenobarbital, and valproic acid) for >6 months in Dr. Soetomo Hospital from January to May 2018. Single and multiple AED group were compared. Peripheral blood 25-OHD levels were measured using enzyme-linked fluorescence assay method with VIDAS® reagent. Vitamin D status was defined 25-OHD level according to International Osteoporosis Foundation (deficiency <20 ng/ml, insufficiency 20-29 ng/ml, and sufficiency >29 ng/ml). The comparison between groups was tested using t-test. (P<0.05 was considered significant).
Results : A total of 30 children, 17/30 were boys, participated in the study with the mean age was 7.3 (SD 3.33) years. Vitamin D deficiency was identified in 2/15 single AED and 8/15 in multiple AED group. The mean of 25-OHD levels in single and multiple AED group were 26.6 (SD 5.29) ng/ml and 20.2 (SD 4,25) ng/ml. There was a significant difference between groups (mean difference 6.1 ng/ml, 95% confidence interval, P=0.001).
Conclusions : Children with single and multiple AED have low levels of 25-OHD, however, multiple AED is lower than single AED. The study of vitamin D supplementation in epileptic children with long-term AED is needed.
Keywords: epilepsy antiepileptic drugs 25-hydroxyvitamin D